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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T1176 | Racecadotril | Acetorphan | Neprilysin , Proteasome |
Racecadotril (Acetorphan) has been investigated for the basic science and treatment of Diarrhea, Acute Diarrhea, and Acute Gastroenteritis. | |||
T7693 | Thiorphan | Neprilysin | |
Thiorphan is an neprilysin inhibitor (NEP; IC50 : 0.007 μM). | |||
TQ0106 | Sacubitrilat | LBQ-657 | Neprilysin |
Sacubitrilat (LBQ-657) (LBQ657) is an effective inhibitor of active neprilysin (NEP). | |||
T4574 | Sacubitril | AHU 377,AHU377,AHU-377 | Neprilysin |
Sacubitril (AHU-377) is a potent NEP inhibitor with an IC50 of 5 nM. Sacubitril is a component of the heart failure medicine LCZ696. | |||
T4200 | Sacubitril hemicalcium salt | AHU-377 (hemicalcium salt),AHU377 calcium salt | Neprilysin |
Sacubitril hemicalcium salt (AHU377 calcium salt) is a potent NEP inhibitor with an IC50 of 5 nM. Sacubitril hemicalcium salt is a component of the heart failure medicine LCZ696. Sacubitril hemicalcium salt is a prodrug ... | |||
T2318 | Sacubitril/Valsartan | Sacubitril mixture with Valsartan,Valsartan,Sacubitril,LCZ696 | Apoptosis , RAAS , Neprilysin |
Sacubitril/Valsartan (LCZ696) is an orally bioavailable, dual angiotensin II receptor and neprilysin inhibitor for the treatment of hypertension and heart failure. | |||
T10918 | NEP-IN-1 | Neprilysin | |
NEP-IN-1 is an inhibitor of neutral endopeptidase (NEP, IC50 = 2 nM) and can be used in studies about female sexual arousal disorders. | |||
T19626 | LHW090-A7 | Neprilysin | |
LHW090-A7 is an neutral endopeptidase (NEP) inhibitor, and an enzyme responsible for the metabolic inactivation of enkephalins. | |||
T27119L | (Rac)-Daglutril | SLV 306 acetic acid,2-((3S)-3-(1-(2-(ethoxycarbonyl)-4-phenylbutyl)cyclopentane-1-carboxamido)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)acetic acid | Others |
(Rac)-Daglutril (SLV 306 acetic acid) is the racemate form of Daglutril. Daglutril is an orally active, mixed neutral endopeptidase/endothelin converting enzyme inhibitor under development for the treatment of essential ... | |||
TP1917L1 | Sar-[D-Phe8]-des-Arg9-Bradykinin acetate | Sar-[D-Phe8]-des-Arg9-Bradykinin acetate(126959-88-4 free base) | Bradykinin Receptor |
Sar-[D-Phe8]-des-Arg9-Bradykinin acetate is a potent and selective bradykinin B1 receptor agonist (EC50 = 9.02 nM in rabbit aorta) that is resistant to aminopeptidase, kininase I and II (ACE) and neutral endopeptidase cl... | |||
T23698 | Aladotril | BP1137,BP 1137,BP-1137 | |
Aladotril is an inhibitor of neutral endopeptidase. Its prodrug is aladotrilat. | |||
T23699 | Aladotrilat | Fasidotrilat | |
Aladotrilat is an inhibitor of neutral endopeptidase. Its prodrug is aladrotril. | |||
T15696 | NEP-IN-2 | Others | |
NEP-IN-2 is an inhibitor of neutral endopeptidase. It also is used in the research of proliferation in atherosclerosis, restenosis. | |||
T28715 | Sch 34826 | Sch34826,Sch-34826 | |
Sch 34826 is a potent, selective neutral endopeptidase inhibitor. | |||
T12994 | SQ28603 | Squibb 28603,SQ28,603 | Others |
SQ28603 is a potent and selective neutral endopeptidase 3.4.24.11 (NEP) inhibitor. | |||
T70567 | CGS 25462 | ||
CGS 25462 is a neutral endopeptidase (NEP) inhibitor. | |||
T31598 | Ecadotril | S.049,BAY-y 7432,BAY y 7432,BP 1.02,S049 | |
Ecadotril is a neutral endopeptidase (NEP) inhibitor, which plays an anti hypertensive role. | |||
T70698 | MDL-100173 | ||
MDL-100173 is a dual angiotensin-converting enzyme (ACE)/neutral endopeptidase (NEP) inhibitor. | |||
T29053 | UK-447841 | UK 447841 | |
UK-447841, a neutral endopeptidase (NEP) inhibitor, is used potentially for the treatment of female sexual dysfunction. | |||
T26048 | RB 101 | RB101,RB-101 | |
RB 101 suppresses enkephalinase and aminopeptidases; biologically cleaved at disulfide to produce inhibitors of both aminopeptidase N and neutral endopeptidase. | |||
T30701 | Candoxatrilat | UK69578,UK 69578,U 73967,U-73967,U73967,UK-69578 | |
Candoxatrilat (U 73967, UK69578) is an active neutral endopeptidase inhibitor that reduces atrial natriuretic peptide degradation. | |||
T16840 | Sampatrilat | UK-81252 | Others |
Sampatrilat is an effecive and orally active vasopeptidase inhibitor of ACE and neutral endopeptidase. Sampatrilat inhibits C-domain ACE (Ki=13.8 nM) 12.4-fold more potent than that for the N-domain (Ki=171.9 nM). | |||
T70471 | Cgs 26303 | ||
Cgs 26303 is a potent non-peptidic inhibitor of neutral endopeptidase capable of protecting atrial natriuretic peptide from enzymatic degradation. | |||
T29052 | UK-414,495 | UK 414495,UK414,495,UK414495,UK-414495 | |
UK-414,495 is a potent, selective inhibitor of the neutral endopeptidase, the enzyme normally serves to break down the neuropeptide VIP. | |||
T68601 | Azidothiorphan | ||
Azidothiorphan is a photoaffinity ligand for the active site of the neutral endopeptidase 24.11. After ultraviolet irradiation the inhibitor binds irreversibly to the enzyme, and photolabeling occurs at the active site.... | |||
TP1917 | Sar-[D-Phe8]-des-Arg9-Bradykinin | ||
Potent and selective bradykinin B1 receptor agonist (EC50 = 9.02 nM in rabbit aorta) that is resistant to aminopeptidase, kininase I and II (ACE) and neutral endopeptidase cleavage. Exhibits hypotensive and angiogenic ac... | |||
T37890 | GLP-1(28-36)amide | ||
GLP-1(28-36)amide, a C-terminal nonapeptide derived from the cleavage of GLP-1 by neutral endopeptidase (NEP), is a significant product. It functions as an antioxidant and primarily targets the mitochondrion, where it ef... | |||
T36943 | Aminopeptidase N Inhibitor | ||
Aminopeptidase N (AP-N) inhibitor is a reversible inhibitor of AP-N/CD13 (IC50 = 25 μM). It is selective for AP-N/CD13 over matrix metalloproteinase-9 (MMP-9), angiotensin converting enzyme (ACE), neutral endopeptidase (... | |||
T61095 | SCH-42354 | ||
SCH-42354 is a potent, orally active inhibitor of neutral endopeptidase (NEP), serving as the active form of the prodrug SCH-42495. By inhibiting NEP hydrolysis, SCH-42354 enhances the activity of atrial natriuretic pept... | |||
T76191 | GLP-1(28-36)amide TFA | ||
GLP-1(28-36)amide TFA, a C-terminal nonapeptide derived from GLP-1 cleavage by neutral endopeptidase (NEP), acts as an antioxidant targeting mitochondria. It inhibits mitochondrial permeability transition (MPT), exhibiti... | |||
T81444 | PL-3994 | ||
PL-3994, a natriuretic peptide receptor-A (NPR-A) agonist resistant to neutral endopeptidase, functions as a bronchodilator, eliciting a concentration-dependent relaxation of pre-contracted guinea-pig trachea, evidenced ... |
カタログ番号 | 製品名 | 別名 | ターゲット |
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T6627 | Phosphoramidon Disodium | Phosphoramidon Disodium Salt | RAAS , Neprilysin , Others |
Phosphoramidon Disodium (Phosphoramidon Disodium Salt) Salt is a metalloendopeptidase inhibitor, widely used as a biochemical tool. | |||
T1168 | Desonide | Tridesilon,Locapred,Prednacinolone | Glucocorticoid Receptor |
Desonide (Prednacinolone) is a synthetic glucocorticosteroid for topical use, with anti-inflammatory activity. Desonide binds to glucocorticoid receptors in the cytoplasm, and the ligand-receptor complex is translocated ... |